A strategy that is effective in reducing the prevalence of infections within a community is empirical treatment. This is where the contact of a proven case of gonorrhoea, chlamydia, trichomoniasis or non-specific urethritis (NSU) is treated on the day they are interviewed and investigated, rather than waiting until the results are back. Treatment should be offered regardless of whether the contact is symptomatic or not.
Rationale for empirical treatment:
- these infections are highly infectious so there is a high probability that the contacts are infected
- the contact interview may be the only opportunity there is for treatment if considered to be in a high risk group e.g. itinerant, homeless, has mental health issues, drug and alcohol use
- the earlier treatment is initiated reduces the risk of reinfection and may reduce complications and further transmission in the community.
If GeneXpert point-of-care test is available, contacts can be treated on the basis of their point-of-care test result.
Syphilis testing and treatment can be more complicated, ideally serology results should be reviewed before treatment is commenced for asymptomatic contacts of syphilis. However, persons who were sexually exposed to a index case with infectious syphilis (primary, secondary, or early latent) should be tested and treated presumptively. If in doubt, offer the contact empirical treatment, (e.g. Benzathine penicillin 1.8 g intramuscularly as a single dose) especially if there is potential for onward transmission if the contact is infected.